A major side effect of Metformin Hcl 500 Mg a commonly prescribed medication for type 2 diabetes, is gastrointestinal discomfort. Gastrointestinal side effects include nausea, vomiting, diarrhea, and abdominal discomfort. These symptoms can be more pronounced when initiating treatment or with higher doses. However, they often diminish over time as the body adjusts to the medication.Metformin Hydrochloride 500 Mg In rare cases, metformin may cause lactic acidosis, a serious condition, particularly in individuals with kidney or liver issues. Regular monitoring and consultation with healthcare professionals help manage side effects and ensure safe and effective use of metformin for controlling blood sugar levels in diabetes.